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They just may not be enough on their own once NAD+ depletion has already begun
The N-terminal part with a sequence of 15 amino acids seems to be the most responsible for the biological activity of the entire protein
It is widely present in animal and plant cells, mainly responsible for clearing reactive oxygen species and free radicals, protecting cells from oxidative damage, and participating in the bodys detoxification process
thus, potentially accounting for the lack of effective deletion observed
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